據(jù)澳大利亞媒體報(bào)道,，科學(xué)家用成年人的干細(xì)胞在試管內(nèi)，用生長(zhǎng)激素和其它生長(zhǎng)因子，種出棕色脂肪細(xì)胞,。因?yàn)榭梢苑N植棕色脂肪細(xì)胞的事實(shí),，科學(xué)家希望有朝一日可以將棕色脂肪細(xì)胞移植入癡肥人士體內(nèi)，幫助加快燃燒卡路里,?？茖W(xué)家可以選擇研發(fā)藥物，刺激人體內(nèi)的棕色脂肪增長(zhǎng),，幫助減肥,。領(lǐng)導(dǎo)這項(xiàng)研究的內(nèi)分泌學(xué)家李保羅醫(yī)生表示，棕色脂肪可以作為“緩沖”,，助抗拒體重增加,。
小小50至60克的棕色脂肪，一日可燒脂約300卡路里,。原來(lái)嬰兒出生時(shí)均有棕色脂肪,，分布于嬰兒的頸后，背部及腎臟周?chē)?，主要是透過(guò)脂肪酸氧化提供體熱的產(chǎn)生保暖作用,。大部分成年人體內(nèi)均存留棕色脂肪。
不過(guò),，李醫(yī)生表示不能單靠移植或服用藥物,，人們?nèi)砸鲞\(yùn)動(dòng)及健康的飲食。最后仍然要靠個(gè)別人士的生活方式,，因?yàn)橹恍鑾讉€(gè)動(dòng)作便可減低甚至抵消棕色脂肪的效力,。
他認(rèn)為近幾十年癡肥人數(shù)增加，可能與人類(lèi)體內(nèi)的棕色脂肪減少有關(guān),。一個(gè)論據(jù)是全球暖化,。“我并非指溫室效應(yīng)，而是人們將室內(nèi)環(huán)境暖化,，所以棕色脂肪無(wú)須增長(zhǎng)。”他說(shuō),。
與此同時(shí),，他正擴(kuò)大研究不同的方法種植棕色脂肪。李醫(yī)生的研究刊登在《內(nèi)分泌學(xué)》（Endocrinology ）上,。（生物谷 Bioon.com）
doi:10.1210/en.2011-1349
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Inducible Brown Adipogenesis of Supraclavicular Fat in Adult Humans
Paul Lee, Michael M. Swarbrick, Jing Ting Zhao and Ken K. Y. Ho
Brown adipose tissue (BAT) plays key roles in thermogenesis and energy homeostasis in rodents. Metabolic imaging using positron emission tomography (PET)-computer tomography has identified significant depots of BAT in the supraclavicular fossa of adult humans. Whether supraclavicular fat contains precursor brown adipocytes is unknown. The aim of the present study was to determine the adipogenic potential of precursor cells in human supraclavicular fat. We obtained fat biopsies from the supraclavicular fossa of six individuals, as guided by PET-computer tomography, with paired sc fat biopsies as negative controls. Each piece of fat tissue was divided and processed for histology, gene analysis, and primary culture. Cells were examined for morphological changes in culture and harvested for RNA and protein upon full differentiation for analysis of UCP1 level. Histological/molecular analysis of supraclavicular fat revealed higher abundance of BAT in PET-positive than PET-negative individuals. In all subjects, fibroblast-like cells isolated from supraclavicular fat differentiated in vitro and uniformly into adipocytes containing multilobulated lipid droplets, expressing high level of UCP1. The total duration required from inoculation to emergence of fibroblast-like cells was 32–34 and 40–42 d for PET-positive- and PET-negative-derived samples, respectively, whereas the time required to achieve full differentiation was 7 d, regardless of PET status. Precursor cells from sc fat failed to proliferate or express UCP1. In summary, preadipocytes isolated from supraclavicular fat are capable of differentiating into brown adipocytes in vitro, regardless of PET status. This study provides the first evidence of inducible brown adipogenesis in the supraclavicular region in adult humans.
