生物谷報道：上?？茖W(xué)家最近發(fā)現(xiàn)一種關(guān)鍵化合物，該化合物可能能夠用于合成II型糖尿病患者和減肥人群的口服藥物,。該研究中的發(fā)現(xiàn)（一種名為Boc5的化合物,，它在自然界中并不存在）---發(fā)表于《美國國家科學(xué)院院報》本周的在線版本上。
受到當?shù)丶爸醒胝推渌鼇碓吹馁Y金支持,，上海藥物研究所的研究人員開發(fā)了一種化合物被證明具有抗糖尿病特性,。給予Boc5的正常老鼠食物攝取明顯減少。該化合物同樣可以預(yù)防體重增加,，并使糖尿病動物的血糖水平正?；Ｔ撗芯勘砻?，Boc5可能代表一類無需通過注射即可治療糖尿病,、肥胖和相關(guān)代謝紊亂的新小分子家族。Boc5化合物口服有效,，因為長期口服該藥物后不會使糖尿病老鼠產(chǎn)生明顯的副作用,。
II型糖尿病是一類非胰島素依賴性疾病。 根據(jù)該研究發(fā)現(xiàn),，研究人員將更進一步致力于研發(fā)含有該化合物的新型藥物用于治療糖尿病,。
Fig. 3. The acute effect of Boc5 on food intake in female C57BL/6 mice.
(a) Cumulative food intake up to 12 h after various i.p. doses of Boc5. Exenatide (1 µg) was used as control. (b) Dose–response characteristics. ED50 was estimated based on 9–10 measurements per group as a shared parameter for all time points. Hill slope was also shared. (c) Blockade of the 30-min anorectic effect of i.p. Boc5 at 1 mg by prior i.p. injection of exendin(9–39) at 10 µg. (d and e) Time course (d) and dose–response (e) of gavaged Boc5 on cumulative food intake. (f) Blockade of the 90-min anorectic effect of gavaged Boc5 (10 mg) by prior i.p. injection of exendin(9–39) at 15 µg. Symbols are means ± SEM, and asterisks indicate P < 0.05 in all panels. Ex(9–39), exendin(9–39).
原文出處：
MEDICAL SCIENCES:
Desu Chen, Jiayu Liao, Na Li, Caihong Zhou, Qing Liu, Guangxing Wang, Rui Zhang, Song Zhang, Lilin Lin, Kaixian Chen, Xin Xie, Fajun Nan, Andrew A. Young, and Ming-Wei Wang
From the Cover: A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice
PNAS 2007 104: 943-948; published online before print as 10.1073/pnas.0610173104
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COMMENTARIES:
K. G. Murphy and S. R. Bloom
Nonpeptidic glucagon-like peptide 1 receptor agonists: A magic bullet for diabetes?
PNAS 2007 104: 689-690; published online before print as 10.1073/pnas.0610679104
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