法國科研人員的一項(xiàng)最新研究發(fā)現(xiàn)，一種名為“基因轉(zhuǎn)錄激活介質(zhì)”的物質(zhì)是生物細(xì)胞中決定基因表達(dá)的關(guān)鍵因素,。
這項(xiàng)研究是法國原子能委員會(huì)和薩克萊生物技術(shù)研究所合作完成的,。相關(guān)研究報(bào)告已發(fā)表在3月18日出版的《科學(xué)》雜志上。
研究發(fā)現(xiàn),，這種“基因轉(zhuǎn)錄激活介質(zhì)”通過核糖核酸聚合酶分子間的相互直接作用,，將其定位在基因中的不同位置，而這種介質(zhì)的功能紊亂可以導(dǎo)致細(xì)胞的不平衡,，甚至在某些情況下成為致癌因素之一,。（生物谷Bioon.com）
生物谷推薦原文出處：
Science DOI: 10.1126/science.1200188
Direct Interaction of RNA Polymerase II and Mediator Required for Transcription in Vivo
Julie Soutourina1,*, Sandra Wydau1,?, Yves Ambroise2, Claire Boschiero1, and Michel Werner1,*
Gene transcription is highly regulated. Altered transcription can lead to cancer or developmental diseases. Mediator, a multisubunit complex conserved among eukaryotes, is generally required for RNA polymerase II (Pol II) transcription. An interaction between the two complexes is known, but its molecular nature and physiological role are unclear. We identify a direct physical interaction between the Rpb3 Pol II subunit of Saccharomyces cerevisiae and the essential Mediator subunit, Med17. Furthermore, we demonstrate a functional element in the Mediator–Pol II interface that is important for genome-wide Pol II recruitment in vivo. Our findings suggest that a direct interaction between Mediator and Pol II is generally required for transcription of class II genes in eukaryotes.
