2月10日,，日本京都大學(xué)等組成的研究團(tuán)隊(duì)在美國在線科學(xué)雜志PLoS ONE上發(fā)表研究成果稱,，番茄中包含能有效改善代謝綜合癥的體脂肪燃燒成分。
造成代謝綜合癥的原因之一是中性脂肪增多導(dǎo)致血脂過高,。京大食品功能學(xué)教授河田照熊介紹說：“這是首次發(fā)現(xiàn)番茄中的成分具有直接燃脂效果,。”
該成分與可有效減少中性脂肪的亞油酸屬同類物質(zhì)。雖然番茄被認(rèn)為對高血脂和糖尿病有效,，但此前其具體有效成分并不為人所知。
研究團(tuán)隊(duì)在番茄及其果汁中尋找激活燃脂基因的物質(zhì),，發(fā)現(xiàn)了這一新成分,。
該團(tuán)隊(duì)對肥胖老鼠進(jìn)行了為期4周的實(shí)驗(yàn)。每天在老鼠食用的4g高卡路里飼料中加入0.002克該成分,，然后與僅喂養(yǎng)高卡路里飼料的肥胖老鼠進(jìn)行中性脂肪量和血糖值的測定比較,。結(jié)果顯示，飼料中加入該成分的老鼠血液和肝臟中的中性脂肪減少了約三成,，血糖值降低了約兩成,。有分析認(rèn)為，這是由于肝臟的糖分吸收能力轉(zhuǎn)好,，從而降低了血糖值,。（生物谷Bioon.com）
doi:10.1371/journal.pone.0031317
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Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice
Young-il Kim, Shizuka Hirai, Tsuyoshi Goto, Chie Ohyane, Haruya Takahashi, Taneaki Tsugane, Chiaki Konishi, Takashi Fujii, Shuji Inai, Yoko Iijima, Koh Aoki, Daisuke Shibata, Nobuyuki Takahashi, Teruo Kawada
Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis.
